Localization of Tubular Adaptation to Renal Sodium Loss in Gitelman Syndrome
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چکیده
منابع مشابه
Localization of tubular adaptation to renal sodium loss in Gitelman syndrome.
BACKGROUND AND OBJECTIVES Gitelman syndrome (GS) is a salt-wasting tubulopathy that results from the inactivation of the human thiazide-sensitive sodium chloride cotransporter located in the distal convoluted tubule. Tubular adaptation to renal sodium loss has been described and localized in the distal tubule in experimental models of GS but not in humans with GS. DESIGN, SETTING, PARTICIPANT...
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Potassium secretion and sodium-potassium adenosine triphosphatase (Na-K-ATPase) activity in the distal nephron segments are known to be influenced by the dietary intake of K+. This has been attributed to a change in the plasma aldosterone level, which also influences K+ secretion and Na-K-ATPase activity in the distal nephron. To investigate whether or not dietary K+ can modulate Na-K-ATPase ac...
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Hypokalaemia is a common clinical disorder, the cause of which can usually be determined by the patient's clinical history. Gitelman syndrome is an inherited tubulopathy that must be considered in some settings of hypokalaemia. We present the case of a 60-year-old male patient referred to our nephrology department for persistent hypokalaemia. Clinical history was positive for symptoms of orthos...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2012
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.00940111